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KMID : 0364020130460030192
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Korean Journal of Thoracic and Cardiovascular Surgery
2013 Volume.46 No. 3 p.192 ~ p.196
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Pathologic Correlation of Serum Carcinoembryonic Antigen and Cytokeratin 19 Fragment in Resected Nonsmall Cell Lung Cancer
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Lee Seok-Kee
Lee Chang-Young
Kim Dae-Joon
Hong Dae-Jin
Lee Jin-Gu
Chung Kyung-Young
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Abstract
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Background: This study focused on the association between preoperative serum carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (Cyfra 21-1) levels and pathologic parameters in patients with resected non-small-cell lung cancer (NSCLC). Materials and Methods: The records of 527 patients who underwent pulmonary resection of NSCLC were reviewed. The association between preoperative serum CEA and Cyfra 21-1 levels and variables that had p-values of less than 0.05 in a t-test or one-way analyses of variance was analyzed by multiple linear regression. Results: The mean serum CEA and Cyfra 21-1 levels prior to surgery were 6.8±23.1 mg/dL (range, 0.01 to 390.8 mg/dL) and 5.4±12.3 mg/dL (range, 0.65 to 140.2 mg/dL). The serum CEA levels were associated with tumor (T) and lymph node (N) stage and histology. The serum Cyfra 21-1 levels were associated with T stage, tumor size, and histology. Multiple linear regression indicated that serum CEA levels were associated with T (T3/4 vs. T1: b=8.463, p=0.010) and N stage (N2/3 vs. N0: b=9.208, p＜0.001) and histology (adenocarcinoma vs. squamous cell: b=6.838, p=0.001), and serum Cyfra 21-1 levels were associated with tumor size (b=2.579, p＜0.001) and histology (squamous cell vs. adenocarcinoma: b=4.420, p=0.020). Conclusion: Serum CEA level was correlated with T and N stage, and Cyfra 21-1 with tumor size. CEA and Cyfra 21-1 showed histologic correlation. CEA is mainly elevated in adenocarcinoma and Cyfra 21-1 in squamous cell carcinoma. These results might be helpful for predicting pathologic status in preoperative NSCLC.
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KEYWORD
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Carcinoma, non-small cell, lung, Neoplasm biology, Carcinoembryonic antigen (CEA), Cytokeratin 19 fragment (Cyfra 21-1)
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